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Bone regeneration can be possible through grafts or engineered bone replacement when bone defects are larger than the critical size. Decellularized bone extracellular matrix (ECM) is an alternative that is able to accelerate tissue regeneration, while decellularization protocols influence engineered bone quality. The objective of this study was to compare the quality of decellularized bone produced...
Rapid and convenient wound healing is crucial for reducing potential post‐traumatic wound complications. In this study, a temperature‐sensitive polymer of poly‐(HEMA‐co‐NIPAM) (PHN) was synthesized by free‐radical polymerization, in which the solution quickly underwent a sol–gel transition above 29°C, thus responding to a typical body temperature and facilitating wound sealing. PHN solution incorporated...
In the field of bone regenerative medicine, injectable calcium phosphate cements (CPCs) are used for decades in clinics, as bone void fillers. Most often preformed polymers (e.g., hyaluronic acid, collagen, chitosan, cellulose ethers…) are introduced in the CPC formulation to make it injectable and improve its cohesion. Once the cement has hardened, the polymer is simply trapped in the CPC structure...
Like many other cell types, neuroblastoma cells are also known to respond to mechanical cues in their microenvironment in vitro. They were shown to have mechanotransduction pathways, which result in enhanced neuronal morphology on stiff substrates. However, in previous studies, the differentiation process was monitored only by morphological parameters. Motivated by the lack of comprehensive studies...
The importance of the microstzructure of silicone hydrogels is widely appreciated but is poorly understood and minimally investigated. To ensure comfort and eye health, these materials must simultaneously exhibit both high oxygen and high water permeability. In contrast with most conventional hydrogels, the water content and water structuring within silicone hydrogels cannot be solely used to predict...
Long‐term stability and biological safety are crucial for translation of 3D‐bioprinting technology into clinical applications. Here, we addressed the long‐term safety and stability issues associated with 3D‐bioprinted constructs comprising a cellulose scaffold and human cells (chondrocytes and stem cells) over a period of 10 months in nude mice. Our findings showed that increasing unconfined compression...
To effectively apply microwell array cell delivery devices their biodegradation rate must be tailored towards their intended use and implantation location. Two microwell array devices with distinct degradation profiles, either suitable for the fabrication of retrievable systems in the case of slow degradation, or cell delivery systems capable of extensive remodeling using a fast degrading polymer,...
We report on the fabrication of a microneedle‐based electrochemical biosensor for use in transdermal biosensing, which includes a screen‐printed electrode containing a Prussian blue‐gold nanohybrid as the working electrode. The Prussian blue gold nanohybrid is made from polyethylenime (PEI)‐ mediated simultaneous synthesis of Prussian blue (PBNP) and gold nanoparticles (AuNP), which forms a PBNP‐AuNP...
This study evaluated the impact of rotor angle and time of storage after centrifugation on the in vitro biological properties of platelet‐rich fibrin (PRF) membranes. Blood samples (n = 9) were processed with a vertical fixed‐angle (V) or a swing‐out horizontal (H) centrifuge, with 20–60 min of sample storage after centrifugation. Leukocytes, platelets, and red blood cells were counted, and fibrin...
A soft tissue defect is often an unavoidable consequence of various surgical procedures or a result of trauma. Recently, intraoperative use of xenograft as a patch to the soft tissue defect has become popular with various products available in the market. In this study, mechanical properties of the OrthADAPT™ Bioimplants (Pegasus Biologics, Irvine, CA), new xenograft products composed of collagen...
Varicose veins are chronic venous defects that affect >20% of the population in developed countries. Among potential treatments, sclerotherapy is one of the most commonly used. It involves endovenous injection of a surfactant solution (or foam) in varicose veins, inducing damage to the endothelial layer and subsequent vessel sclerosis. Treatments have proven to be effective in the short‐term, however...
Using silk fibroin as the base material, the drug‐loaded microspheres are prepared by an emulsification method. In order to determine the drug‐loading and drug‐release performance parameters of the microspheres, the central composite design method is used to design and investigate the effects of the parameters of the microsphere preparation process, such as the oil–water ratio, stirring temperature,...
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